ABSTRACT
Introduction@#Nowadays, there is a growing trend to use natural medicines with low side effects, and research on medicinal raw materials used in traditional medicine has become more widespread. Therefore, it is important to obtain a suitable drug form from <i>Plantago Major</i> L and to conduct chemical and pharmaceutical technology research.@*Material and method@#The research was conducted in the pharmaceutical industry and technology laboratory. A granule formulation with several variants consisting of a concentrated extract and excipients was obtained. The sum of flavonoids of <i>Plantago Major</i> L extracts and Granular Dosage Forms was detected by thin-layer chromatography in a suitable solvent system prepared in the ratio of ethyl acetate, formic acid, glacial acetic acid, and water (100: 11:11:26). The total flavonoid content of the drug forms was determined by spectrophotometry.@*Result@#Technological researches were carried out with lactose and glucose fillers, gelatin 8%, polyvinyl chloride (PVP) 6%, starch 5% binders, talc 1%, magnesium stearate 1% sliding and lubricating agents and the wet granulation method was used to obtain granules in several variants and was determined by using parameters such as particle spill weight and flow quality. In this research, the flow rate of <i>Plantago Major</i> L grains with lactose as a filler and PVP as a binder was -2.8 ± 0.18 g / sec (p <0.001) and the spill weight was -0.54 ± 0.03 g /cm3 (p <0.001). Based on the results of the above research, lactose was added as a filler, PVP as a binder, 6% as a slide and lubricant, 3% as talc and 1% as magnesium stearate, and the granular drug technology was developed by wet granulation. Analysis of the total flavonoids by thin-layer chromatography revealed the same level of yellow-brown spots (Rf = 0.4) on the plate. The total flavonoid content of the granules from <i>Plantago Major</i> L was 3.8 ± 0.2% (p <0.002).@*Conclusion@#In this study, a simple and suitable drug formulation from <i>Plantago Major</i> L was successfully obtained and it was a basic research to make new drug formulations in further needs.
ABSTRACT
Abstract@#We have worked on the research related with total flavonoid isolated Rhododendron Adamsii Rehder, which enhance and restore physical energy and reduce mental pain. According to the result, the highest amount (2.4±0.007%) of the total flavonoids was found in the 40% ethanol extract of Rhododendron Adamsii Rehder at 60 minutes of extraction time. Subsequently, the granulated formulation from the extract of Rhododendron Adamsii Rehder was prepared by using 4% of gelatin, 4% of polyvinylchloride and 4% of carboxymethyl cellulose. The fluidity and pouring weight of the granule was evaluated and 4% of gelatin was chosen as the suitable binder for the formulation. In conclusion, we have successfully developed the granulated formulation from Rhododendron Adamsii Rehder.